| James Carpinello Injured during a rehearsal while in previews | Sonny | Was replaced in previews |
| Whoopi Goldberg | Calliope, Aphrodite | (Jul 29, 2008-Sep 7, 2008) |
| Jackie Hoffman | Calliope, Aphrodite | (Sep 9, 2008 - ?) |
| Curtis Holbrook Steps into the role of Sonny while Cheyenne Jackson takes July leave to perform with City Center Encores!. | Sonny | (Jul 1, 2008-Jul 27, 2008) |
| Kyle Dean Massey | Thalia, Siren, Young Danny, '80s Singer, Cyclops | (Apr 15, 2008 - ?) |
| Patti Murin | Euterpe, Siren, '40s Singer, Thetis | (Nov 27, 2007 - ?) |